Pyrrolidine → HCID 178505172, compound

HRID 2083965Notes

Reaction equation

HRID 2083965 reaction equation
[NH2:1][C:2]([NH:4][CH2:5][CH2:6][S:7][CH2:8][C@H:9]([C:21]([OH:23])=O)[NH:10]C(OCC1C=CC=CC=1)=O)=[NH:3].[CH3:24][S:25]([Cl:28])(=[O:27])=[O:26].[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[ClH:28].[NH:3]=[C:2]([NH:4][CH2:5][CH2:6][S:7][CH2:8][C@H:9]([C:21]([N:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1)=[O:23])[NH2:10])[NH:1][S:25]([CH3:24])(=[O:27])=[O:26]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 31297Methanesulfonyl chlorideHCID 178513030HCID 178513030, compound

Product 1

HCID 178505172HCID 178505172, compound

Procedure

Starting from (S)-3-(2-{[amino-(imino)-methyl]-amino}-ethylthio)-N-(benzyloxy-carbonyl)-alanine, methanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 1.

Sources & evidence

ORD record
ord-2b7ef23305ac463ca6e0efb5c77ece88
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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