Pyrrolidine → HCID 69890658, compound

HRID 2083972Notes

Reaction equation

[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:24]([OH:26])=O)[CH2:13][CH2:14][CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:24](=[O:26])[N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:13][CH2:14][CH2:15][NH:16][C:17]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:18])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 7350734Z-Ndelta-Boc-L-ornithine

Product 1

HCID 69890658HCID 69890658, compound

Procedure

Starting from (S)-N2-(benzyloxycarbonyl)-N5-(tert-butyloxycarbonyl)-ornithine and pyrrolidine, the expected product is obtained according to the procedure described in Step A of Example 3.

Sources & evidence

ORD record: ord-10418aaebe7248898a6a16e83500d028
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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