Pyrrolidine → HCID 69891063, compound

HRID 2083975Notes

Reaction equation

C(OC([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:25]([OH:27])=O)[NH:17]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH:28]1([S:34]([Cl:37])(=[O:36])=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.[NH:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1>>[ClH:37].[NH2:17][C@H:16]([C:25](=[O:27])[N:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1)[CH2:15][CH2:14][CH2:13][CH2:12][NH:11][S:34]([CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)(=[O:36])=[O:35]

Participants

Reactant 3

HCID 31268Pyrrolidine

HCID 237554Cyclohexanesulfonyl chloride

HCID 2724765Boc-Lys(Z)-OH

Product 1

HCID 69891063HCID 69891063, compound

Procedure

Starting from (S)-N6-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-lysine, cyclohexanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 3.

Sources & evidence

ORD record: ord-6f84a3913a174bc888669b5f47abd9b5
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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