Pyrrolidine → HCID 69891008, compound

HRID 2083980Notes

Reaction equation

HRID 2083980 reaction equation
C(O[C:9]([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([OH:26])=O)[NH:16]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH:27]1([S:33]([Cl:36])(=[O:35])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1.[NH:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1>>[ClH:36].[NH2:16][C@H:15]([C:24](=[O:26])[N:37]1[CH2:41][CH2:40][CH2:39][CH2:38]1)[CH2:14][CH2:13][CH2:12][N:11]([CH3:9])[S:33]([CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)(=[O:35])=[O:34]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 237554Cyclohexanesulfonyl chlorideHCID 7269338(2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoic acid

Product 1

HCID 69891008HCID 69891008, compound

Procedure

Starting from (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine, cyclohexanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 68.

Sources & evidence

ORD record
ord-a545063ea094446299ecd9d16ff95983
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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