Dichloromethane → Trifluoroacetic acid

HRID 208403Notes

Reaction equation

HRID 208403 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:17]#[N:18])[cH:14][c:15]2[CH2:16]1)([CH3:5])([CH3:6])[CH3:7].[Cl:26][CH2:27][Cl:28].[F:19][C:20]([C:21](=[O:22])[OH:23])([F:24])[F:25]>>[F:19][C:20]([C:21](=[O:22])[OH:23])([F:24])[F:25].[NH:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:17]#[N:18])[cH:14][c:15]2[CH2:16]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 18630967tert-Butyl 5-cyano-1,3-dihydro-2H-isoindole-2-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 179862802,3-Dihydro-1H-isoindole-5-carbonitrile

Sources & evidence

ORD record
ord-fe8efdede095444187f9a5522faef3bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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