3-(Trifluoromethyl)aniline → HCID 22732378, compound

HRID 2084088Notes

Reaction equation

HRID 2084088 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[NH2:15][C:16]1[CH:17]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:20][CH:21]=1>>[F:23][C:22]([F:24])([F:25])[C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[NH:15][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

Product 1

HCID 22732378HCID 22732378, compound

Procedure

The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-aminobenzotrifluoride (30 μl, 0.243 mmol) similar to Example 11 and isolated as a pale white solid (74 mg, 93%). 1H NMR (CDCl3): 8.84-8.82 (m, 1H), 8.49-8.45 (m, 1H), 7.95 (s, 1H), 7.90-7.85 (m, 1H), 7.62 (d, J=7.8 Hz, 1H), 7.52 (t, J=7.8 Hz, 1H), 7.45-7.40 (m, 2H), 6.78 (s, 1H), 2.55 (s, 3H).

Sources & evidence

ORD record
ord-1e503ccc675c4866978e7ecbfe949cbc
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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