3-(Trifluoromethyl)aniline → HCID 22732378, compound

Participants

Reaction Steps

The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-aminobenzotrifluoride (30 μl, 0.243 mmol) similar to Example 11 and isolated as a pale white solid (74 mg, 93%). 1H NMR (CDCl3): 8.84-8.82 (m, 1H), 8.49-8.45 (m, 1H), 7.95 (s, 1H), 7.90-7.85 (m, 1H), 7.62 (d, J=7.8 Hz, 1H), 7.52 (t, J=7.8 Hz, 1H), 7.45-7.40 (m, 2H), 6.78 (s, 1H), 2.55 (s, 3H).

Provenance & Evidence