2-Methoxy-5-Methylaniline → HCID 10133128, compound

HRID 2084136Notes

Reaction equation

HRID 2084136 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:21]=1[NH2:22]>>[CH3:18][O:19][C:20]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:21]=1[NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 84452-Methoxy-5-MethylanilineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 10133128HCID 10133128, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 2-methoxy-5-methylaniline (40 mg, 0.290 mmol) similar to Example 58 and isolated as a yellow solid (41 mg, 59%). 1H NMR (CDCl3): 9.66 (d, J=1.8 Hz, 1H), 8.74-8.70 (m, 2H), 7.98 (s, 1H), 7.55 (s, 1H), 7.44-7.40 (m, 1H), 6.99-6.95 (m, 1H), 6.88 (s, 1H), 6.85 (s, 1H), 3.89 (s, 3H), 2.40 (s, 3H).

Sources & evidence

ORD record
ord-cb68661f6da94ba3b03f65d4ced2c73d
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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