4-Chloro-2,5-dimethoxyaniline → HCID 22732401, compound

HRID 2084176Notes

Reaction equation

HRID 2084176 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[Cl:18][C:19]1[C:25]([O:26][CH3:27])=[CH:24][C:22]([NH2:23])=[C:21]([O:28][CH3:29])[CH:20]=1>>[ClH:1].[Cl:18][C:19]1[C:25]([O:26][CH3:27])=[CH:24][C:22]([NH:23][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)=[C:21]([O:28][CH3:29])[CH:20]=1

Participants

3

Reactant 2

HCID 228334-Chloro-2,5-dimethoxyanilineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732401HCID 22732401, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4-chloro-2,5-dimethoxyaniline (54 mg, 0.290 mmol) similar to Example 117 and isolated as a brown solid (52 mg, 63%). 1H NMR (CDCl3): 9.66-9.64 (m, 1H), 8.76-8.71 (m, 2H), 8.35 (s, 1H), 7.54 (s, 1H), 7.45-7.41 (m, 1H), 7.01 (s, 1H), 6.92 (s, 1H).

Sources & evidence

ORD record
ord-536e9077171d4a4b9b20c0a22ba17597
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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