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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2084176Generated: November 1, 2026

4-Chloro-2,5-dimethoxyaniline → HCID 22732401, compound

https://huagongshe.com/reaction/2084176

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-2,5-dimethoxyanilineHCID 22833—
Reactant4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 1485990—
ProductHCID 22732401HCID 22732401—

Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4-chloro-2,5-dimethoxyaniline (54 mg, 0.290 mmol) similar to Example 117 and isolated as a brown solid (52 mg, 63%). 1H NMR (CDCl3): 9.66-9.64 (m, 1H), 8.76-8.71 (m, 2H), 8.35 (s, 1H), 7.54 (s, 1H), 7.45-7.41 (m, 1H), 7.01 (s, 1H), 6.92 (s, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06716851B2
Source datasetuspto-grants-2004_04
ORD IDord-536e9077171d4a4b9b20c0a22ba17597
Source noteuspto-grants-2004_04