2-Methoxy-5-Methylaniline → HCID 22732413, compound

HRID 2084229Notes

Reaction equation

HRID 2084229 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:21]=1[NH2:22]>>[CH3:18][O:19][C:20]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:21]=1[NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 84452-Methoxy-5-MethylanilineHCID 227323674-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732413HCID 22732413, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine (40 mg, 0.152 mmol) and 2-methoxy-5-methylaniline (28 mg, 0.231 mmol) similar to example 180 and was isolated as a solid (43 mg, 81%). 1H NMR (CDCl3): 9.73 (m, 1H), 8.44-8.41 (m, 1H), 7.81-7.75 (m, 1H), 7.46 (s, 1H), 7.34-7.28 (m, 2H), 7.23 (t, J=8.1 Hz, 1H), 7.09-7.06 (m, 1H), 7.00-6.97 (m, 1H), 6.55 (d, J=0.6 Hz, 1H), 2.44 (s, 3H), 2.43 (d, J=0.6, 3H).

Sources & evidence

ORD record
ord-70b52cc424d646eab43bce95152de488
Source dataset
uspto-grants-2004_04
Patent number
US06716851B2

Reaction notes

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