4-Chlorobenzoyl chloride → HCID 9802268, compound

HRID 2084301Notes

Reaction equation

HRID 2084301 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][C:15]3[C:16]([NH2:21])=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH:21][C:16]2[C:15]([NH:14][CH2:13][CH:10]3[CH2:11][CH2:12][N:7]([C:4]4[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=4)[CH2:8][CH2:9]3)=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:28])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 12150698N1-[1-(4-pyridyl)piperidin-4-ylmethyl)-1,2-benzenediamine

Product 1

HCID 9802268HCID 9802268, compoundYield 55.2%

Procedure

Using a similar procedure to that described in Example 2, Part D, N1-[1-(4-pyridyl)piperidin-4-ylmethyl)-1,2-benzenediamine (167 mg, 0.59 mmol) and 4-chlorobenzoyl chloride (0.075 mL, 0.59 mmol) yielded 137 mg (55%) of the title compound.

Sources & evidence

ORD record
ord-ea8499bb66a7425b9cce65558071a0f4
Source dataset
uspto-grants-2004_04
Patent number
US06716855B2

Reaction notes

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