HCID 69830277, compound → HCID 12109867, compound

HRID 2084362Notes

Reaction equation

HRID 2084362 reaction equation
C([O:8][CH2:9][C@H:10]([OH:17])[CH2:11][C:12]1[NH:13][CH:14]=[CH:15][N:16]=1)C1C=CC=CC=1.[H][H]>CO.[C].[Pd]>[NH:13]1[CH:14]=[CH:15][N:16]=[C:12]1[CH2:11][C@@H:10]([OH:17])[CH2:9][OH:8]

Participants

5

Reactant 2

HCID 69830277HCID 69830277, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12109867HCID 12109867, compoundYield 97.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of (2R)-1-(benzyloxy)-3-(1H-imidazol-2-yl)-2-propanol (424 mg) in methanol (10 ml), 10% palladium carbon (50% hydrated, 85 mg) was added, followed by stirring at 50-60° C. in a hydrogen atmosphere for 2 days. The catalyst was filtered off; the filtrate was concentrated to yield the titled compound (254 mg) as a white solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-16c911c5cf564035b6fb0b14d201fd51
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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