Potassium Carbonate → HCID 12109871, compound

HRID 2084380Notes

Reaction equation

HRID 2084380 reaction equation
I[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.[OH:19][CH2:20][CH2:21][C:22]1[NH:23][CH:24]=[CH:25][N:26]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][CH2:3][CH2:2][N:23]2[CH:24]=[CH:25][N:26]=[C:22]2[CH2:21][CH2:20][OH:19])=[CH:6][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 11439556HCID 11439556, compoundHCID 150160802-(1H-imidazol-2-yl)ethan-1-ol

Product 1

HCID 12109871HCID 12109871, compoundYield 55.1%

Procedure

Using benzyl 4-(3-iodopropyl)phenyl ether (5.28 g), 2-(2-hydroxyethyl)imidazole (5.05 g) and potassium carbonate (2.07 g), the same reaction as Reference Example 12-(i) was carried out to yield the titled compound (2.78 g) as colorless crystals.

Workup

  1. customthe same reaction as Reference Example

Sources & evidence

ORD record
ord-7188f7beb5e944cd97a0221a04eba149
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

Loading…