2-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol → 3-{3-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]propyl}phenol

HRID 2084383Notes

Reaction equation

HRID 2084383 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[C:19]2[CH2:23][CH2:24][OH:25])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[C].[Pd]>[OH:25][CH2:24][CH2:23][C:19]1[N:18]([CH2:17][CH2:16][CH2:15][C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=2)[CH:22]=[CH:21][N:20]=1

Participants

3

Reactant 1

HCID 227333732-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol

Product 1

HCID 227333553-{3-[2-(2-hydroxyethyl)-1H-imidazol-1-yl]propyl}phenolYield 95.4%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

Using 2-(1-{3-[3-(benzyloxy)phenyl]propyl)-1H-imidazol-2-yl)-1-ethanol (2.42 g) and 10% palladium carbon (0.24 g), the same reaction as Reference Example 11-(v) was carried out to yield the titled compound (1.69 g) as colorless crystals.

Workup

  1. customthe same reaction as Reference Example 11-(v)

Sources & evidence

ORD record
ord-efc05f0e23214bf391183e3a876b8e22
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

Loading…