3-{1-[4-(4-benzyloxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol → 3-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl)-1,2-propanediol

HRID 2084385Notes

Reaction equation

HRID 2084385 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[CH:22][N:21]=[C:20]2[CH2:24][CH:25]([OH:28])[CH2:26][OH:27])=[CH:11][CH:10]=1)C1C=CC=CC=1>[C].[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[CH:22][N:21]=[C:20]2[CH2:24][CH:25]([OH:28])[CH2:26][OH:27])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 227333803-{1-[4-(4-benzyloxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol

Product 1

HCID 121098723-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl)-1,2-propanediolYield 98.6%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

Using 3-{1-[4-(4-benzyloxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol (1.22 g) and 10% palladium carbon (0.18 g), the same reaction as Reference Example 11-(v) was carried out to yield the titled compound (0.918 g) as colorless crystals.

Workup

  1. customthe same reaction as Reference Example 11-(v)

Sources & evidence

ORD record
ord-b40fbed80b3c44e38dc40df602416872
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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