4-(4-Hydroxybutyl)phenol → HCID 22733356, compound

HRID 2084389Notes

Reaction equation

HRID 2084389 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][OH:12])=[CH:4][CH:3]=1.Cl[CH2:14][C:15]1[N:16]=[C:17](/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][CH:23]=2)[O:18][CH:19]=1>>[Br:28][C:25]1[CH:26]=[CH:27][C:22](/[CH:21]=[CH:20]/[C:17]2[O:18][CH:19]=[C:15]([CH2:14][O:1][C:2]3[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][OH:12])=[CH:6][CH:7]=3)[N:16]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 133925134-(4-Hydroxybutyl)phenolHCID 22259301HCID 22259301, compound

Product 1

HCID 22733356HCID 22733356, compoundYield 91%

Procedure

Using 4-(4-hydroxyphenyl)-1-butanol (4.99 g) and (E)-4-chloromethyl-2-[2-(4-bromophenyl)ethenyl]oxazole (7.43 g), the same reaction as Reference Example 17-(i) was carried out to yield 4-[4-[2-(E)-[2-(4-bromophenyl)ethenyl]-1,3-oxazol-4-yl]methoxyphenyl]-1-butanol (9.70 g). Using the compound obtained (4.28 g), the same reaction as Reference Example 17-(ii) was carried out to yield the titled compound (4.47 g) as a white powder.

Workup

  1. customthe same reaction as Reference Example

Sources & evidence

ORD record
ord-4e650969743249589a407e08a19f84a3
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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