HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68739915, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(chloromethyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole | HCID 9857126 | — |
| Reactant | HCID 22733371 | HCID 22733371 | — |
| Product | HCID 68739915 | HCID 68739915 | 66.4% |
Reaction Steps
Using 65% sodium hydride (40.6 mg), 4-[3-[2-(hydroxyethyl)-1H-imidazol-1-yl]propyl]phenol (246 mg) and [2-[(E)-2-(4-trifluoromethylphenyl)ethenyl]oxazol-4-yl]methyl chloride (316 mg), the same reaction as Example 17 was carried out to yield the titled compound (330 mg) as colorless needles.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716863B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-6a6a73e771d346f89307e2f362927bb0 |
| Source note | uspto-grants-2004_04 |