Sodium hydride → HCID 68739915, compound

HRID 2084403Notes

Reaction equation

HRID 2084403 reaction equation
[H-].[Na+].[OH:3][CH2:4][CH2:5][C:6]1[N:7]([CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH:8]=[CH:9][N:10]=1.[F:21][C:22]([F:39])([F:38])[C:23]1[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]2[O:32][CH:33]=[C:34]([CH2:36]Cl)[N:35]=2)=[CH:25][CH:24]=1>>[F:39][C:22]([F:21])([F:38])[C:23]1[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]2[O:32][CH:33]=[C:34]([CH2:36][O:20][C:17]3[CH:16]=[CH:15][C:14]([CH2:13][CH2:12][CH2:11][N:7]4[CH:8]=[CH:9][N:10]=[C:6]4[CH2:5][CH2:4][OH:3])=[CH:19][CH:18]=3)[N:35]=2)=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 98571264-(chloromethyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazoleHCID 22733371HCID 22733371, compound

Product 1

HCID 68739915HCID 68739915, compoundYield 66.4%

Procedure

Using 65% sodium hydride (40.6 mg), 4-[3-[2-(hydroxyethyl)-1H-imidazol-1-yl]propyl]phenol (246 mg) and [2-[(E)-2-(4-trifluoromethylphenyl)ethenyl]oxazol-4-yl]methyl chloride (316 mg), the same reaction as Example 17 was carried out to yield the titled compound (330 mg) as colorless needles.

Workup

  1. customthe same reaction as Example 17

Sources & evidence

ORD record
ord-6a6a73e771d346f89307e2f362927bb0
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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