反应详情

To a solution of 4-[4-[2-(2-hydroxyethyl)-1H-imidazol-1-yl ]butyl]phenol (260 mg) in DMF (4 ml), 60% oily sodium hydride (44 mg) was added under ice cooling. After stirring at room temperature for 30 minutes, (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl) ethenyl]oxazole (281 mg) was added under ice cooling. After stirring at room temperature for 3 days, water was added under ice cooling. The precipitate was collected by filtration and washed with water. The precipitate was dissolved in a mixture of ethyl acetate-THF and dried over magnesium sulfate, after which it was concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to yield the titled compound (275 mg) as pale-yellow crystals.

1. stirringAfter stirring at room temperature for 3 days
2. filtrationThe precipitate was collected by filtration
3. washwashed with water
4. dissolutionThe precipitate was dissolved in a mixture of ethyl acetate-THF
5. dry with materialdried over magnesium sulfate
6. concentrationafter which it was concentrated under reduced pressure
7. customThe residue was recrystallized from ethyl acetate-hexane