Sodium hydride → HCID 10229265, compound

HRID 2084409Notes

Reaction equation

HRID 2084409 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[C:13]2[CH2:17][CH:18]([OH:21])[CH2:19][OH:20])=[CH:4][CH:3]=1.[H-].[Na+].Cl[CH2:25][C:26]1[N:27]=[C:28](/[CH:31]=[CH:32]/[C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][C:34]=2[F:40])[O:29][CH:30]=1>>[F:40][C:34]1[CH:35]=[C:36]([F:39])[CH:37]=[CH:38][C:33]=1/[CH:32]=[CH:31]/[C:28]1[O:29][CH:30]=[C:26]([CH2:25][O:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]3[CH:16]=[CH:15][N:14]=[C:13]3[CH2:17][CH:18]([OH:21])[CH2:19][OH:20])=[CH:4][CH:3]=2)[N:27]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 12109498(E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazoleHCID 121098723-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl)-1,2-propanediol

Product 1

HCID 10229265HCID 10229265, compoundYield 62.3%

Procedure

Using 3-{1-[4-(4-hydroxyphenyl)butyl]-1H-imidazol-2-yl}-1,2-propanediol(204 mg), 65% oily sodium hydride (28 mg) and 4-(chloromethyl)-2-[(E)-2-(2,4-difluorophenyl)ethenyl]-1,3-oxazole (188 mg), the same reaction as Example 2 was carried out to yield the titled compound (223 mg).

Workup

  1. customthe same reaction as Example 2

Sources & evidence

ORD record
ord-f5c7110b1b02456b9c0f02287560410e
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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