2-Bromoacetamide → HCID 60077676, compound

HRID 2084482Notes

Reaction equation

HRID 2084482 reaction equation
[NH2:1][CH2:2][C:3]1[N:7]=[C:6]([C@H:8]([CH2:17][CH2:18][CH2:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[O:5][N:4]=1.Br[CH2:27][C:28]([NH2:30])=[O:29]>CCN(CC)CC>[NH2:30][C:28](=[O:29])[CH2:27][NH:1][CH2:2][C:3]1[N:7]=[C:6]([C@H:8]([CH2:17][CH2:18][CH2:19][CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]2)[CH2:9][C:10]([O:12][C:13]([CH3:15])([CH3:16])[CH3:14])=[O:11])[O:5][N:4]=1

Participants

4

Reactant 2

HCID 696322-BromoacetamideHCID 16747946tert-butyl(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate

Product 1

HCID 60077676HCID 60077676, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Method as for preparation 106 using tert-butyl (3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexylhexanoate (preparation 18) (250 mg, 0.71 mmol) and 2-bromoacetamide (98 mg, 0.71 mmol) as starting materials and Et3N as the base.

Sources & evidence

ORD record
ord-856d190241cd433a8ab031afd933fe1e
Source dataset
uspto-grants-2004_04
Patent number
US06716861B2

Reaction notes

Loading…