反应详情

To a solution of (1(S)-acetyl-2,2-dimethylpropyl)carbamic acid-tert-butyl ester (700 mg, 2.55 mmol) in dichloromethane (10 mL) at 0° C. was added trifluoroacetic acid (5 mL). The reaction was left at <5° C. for 16 hours before the solvents were removed in vacuo to give a bright yellow oil. The residue was dissolved in methanol (30 mL) and was treated portionwise with Dowex 1X8-400 basic resin until pH 9. Filtration and removal of the solvents in vacuo gave the title compound as a pale yellow oil (˜1.0 g, >100%, residual water). The material was used without further purification.

1. customwere removed in vacuo
2. customto give a bright yellow oil
3. additionwas treated portionwise with Dowex 1X8-400 basic resin until pH 9
4. filtrationFiltration and removal of the solvents in vacuo