Pyridinium chloride → HCID 22733439, compound

HRID 2084562Notes

Reaction equation

HRID 2084562 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([CH2:11][C:12]3(O)[CH:19]4[CH2:20][CH:15]5[CH2:16][CH:17]([CH2:21][CH:13]3[CH2:14]5)[CH2:18]4)=[N:8][C:7]=2[CH:23]=1.Cl.N1C=CC=CC=1>C(OCC)(=O)C>[CH:13]12[CH2:21][CH:17]3[CH2:16][CH:15]([CH2:20][CH:19]([CH2:18]3)[C:12]1=[CH:11][C:9]1[S:10][C:6]3[CH:5]=[CH:4][C:3]([OH:2])=[CH:23][C:7]=3[N:8]=1)[CH2:14]2

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 22733408HCID 22733408, compound2×

Product 1

HCID 22733439HCID 22733439, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

300 mg 2-(5-methoxy-benzothiazol-2-ylmethyl)adamantan-2-ol (formula IX) and 527 mg pyridine hydrochloride are heated at about 200° for about 30 minutes. The melt obtained is dissolved in 100 ml of ethyl acetate, the mixture is extracted with water, 2.5 M sodium acetate solution and brine, the organic phase dried and the solvent evaporated off. The evaporation residue obtained is subjected to chromatography. The title compound is obtained (m.p. 156-158°).

Workup

  1. customThe melt obtained
  2. extractionthe mixture is extracted with water, 2.5 M sodium acetate solution and brine
  3. customthe organic phase dried
  4. customthe solvent evaporated off
  5. customThe evaporation residue obtained

Sources & evidence

ORD record
ord-5f1190fd3cca404f9ac75f1a0f39bdec
Source dataset
uspto-grants-2004_04
Patent number
US06716865B1

Reaction notes

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