Water → HCID 11148234, compound

HRID 2084692Notes

Reaction equation

HRID 2084692 reaction equation
[Cl:1][CH2:2][C:3](=[O:8])[CH2:4][C:5](Cl)=[O:6].O>ClCCl.FC(F)(F)S([O-])(=O)=O.[Sc+3].FC(F)(F)S([O-])(=O)=O.FC(F)(F)S([O-])(=O)=O>[Cl:1][CH2:2][C:3]1[O:8][C:3]([CH2:2][Cl:1])=[CH:4][C:5](=[O:6])[CH:4]=1

Participants

5

Reactant 2

HCID 962WaterHCID 30162624-Chloro-3-oxobutyryl chloride

Product 1

HCID 11148234HCID 11148234, compoundYield 0.1%

Reagents, catalysts & solvents 2

HCID 2734571Scandium(III) triflateCatalystHCID 6344DichloromethaneSolvent

Procedure

4-Chloroacetoacetyl chloride (14.8 g, 33.4 mol) in dichloromethane (35% strength solution) and scandium trifluoromethanesulphonate (1.45 g, 2.5 mol) were stirred at 25° C. for 6.5 days under a nitrogen atmosphere. Water (10 g, 0.55 mol) was then added and the organic phase was concentrated. 4.2 g of product were obtained (according to GC 68% crude product). After chromatography on a silica gel column, 0.7 g of pure product corresponding to a yield of 10.8% were obtained.

Workup

  1. concentrationthe organic phase was concentrated

Sources & evidence

ORD record
ord-b2811d885fc549a398272922e21d9906
Source dataset
uspto-grants-2004_04
Patent number
US06716999B2

Reaction notes

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