HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 11148234, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Chloro-3-oxobutyryl chloride | HCID 3016262 | — |
| Catalyst | Scandium(III) triflate | HCID 2734571 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11148234 | HCID 11148234 | 0.1% |
Reaction Steps
4-Chloroacetoacetyl chloride (14.8 g, 33.4 mol) in dichloromethane (35% strength solution) and scandium trifluoromethanesulphonate (1.45 g, 2.5 mol) were stirred at 25° C. for 6.5 days under a nitrogen atmosphere. Water (10 g, 0.55 mol) was then added and the organic phase was concentrated. 4.2 g of product were obtained (according to GC 68% crude product). After chromatography on a silica gel column, 0.7 g of pure product corresponding to a yield of 10.8% were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716999B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-b2811d885fc549a398272922e21d9906 |
| Source note | uspto-grants-2004_04 |