Hydrochloric Acid → HCID 22315573, compound

HRID 2084710Notes

Reaction equation

HRID 2084710 reaction equation
[Cl:1][CH:2]([Cl:7])[C:3](OC)=[O:4].C[O-].[Na+].[F:11][C:12]1[CH:13]=[C:14]([C:20](=[O:22])[CH3:21])[CH:15]=[CH:16][C:17]=1[O:18][CH3:19].Cl>CCOCC>[Cl:7][CH:2]([Cl:1])[C:3](=[O:4])[CH2:21][C:20]([C:14]1[CH:15]=[CH:16][C:17]([O:18][CH3:19])=[C:12]([F:11])[CH:13]=1)=[O:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8315Methyl dichloroacetateHCID 968281-(3-Fluoro-4-methoxyphenyl)ethan-1-oneHCID 10942334Sodium Methoxide

Product 1

HCID 22315573HCID 22315573, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Methyl dichloroacetate (1.57 g, 11 mmol) was dissolved ether (25 mL). To the stirred solution was added 25% sodium methoxide (2.38 g, 11 mmol) followed by 3′-fluoro-4′-methoxyacetophenone from Step 1 (1.68 g, 10 mmol). After stirring 10 hours 1N HCl (25 mL) was added. The organic layer was collected and washed with water (2×25 mL), dried over magnesium sulfate, filtered, and concentrated. The resulting crude dione was used in the next step without further purification or characterization.

Workup

  1. additionwas added
  2. customThe organic layer was collected
  3. washwashed with water (2×25 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe resulting crude dione was used in the next step without further purification or characterization

Sources & evidence

ORD record
ord-33870b04910d4c25a5121ada1bd7ab3b
Source dataset
uspto-grants-2004_04
Patent number
US06716991B1

Reaction notes

Loading…