HCID 10471772, compound → HCID 12082818, compound

HRID 2084714Notes

Reaction equation

HRID 2084714 reaction equation
[OH:1][CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1>C(OCC)(=O)C.O=[Mn]=O>[CH:2]([C:3]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 10471772HCID 10471772, compound

Product 1

HCID 12082818HCID 12082818, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the alcohol prepared in Example 131, Step 3 (1.1 g, 3.3 mmol) in ethyl acetate (20 mL) was added MnO2 (5 g, 60 mmol) and the mixture stirred at room temperature overnight. The mixture was filtered through Celite and the solution was concentrated to provide the crude aldehyde.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-33938c61a57c47e68c727c4ac245777b
Source dataset
uspto-grants-2004_04
Patent number
US06716991B1

Reaction notes

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