Pyrrolidine → HCID 40805129, compound

HRID 2084802Notes

Reaction equation

HRID 2084802 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([C:12]([OH:14])=O)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:12]([C:9]2[O:10][C:11]3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=3[CH:8]=2)=[O:14])[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 6060377-Methoxy-1-benzofuran-2-carboxylic acid

Product 1

HCID 40805129HCID 40805129, compound

Procedure

Substantially the same procedure as in Example 219 was repeated using a starting material, 7-methoxybenzofuran-2-carboxylic acid, and pyrrolidine to give 2-Pyrrolidinylcarbonyl-7-methoxybenzofuran (Compound 309a). Successively, it was formylated to give 2-pyrrolidinylcarbonyl-4-formyl-7-methoxybenzofuran (Compound 309b), then compound 309b was reacted with methylamine hydrochloride to give compound 309 as a white solid.

Sources & evidence

ORD record
ord-d292795240ab4794a8ab0f6346a60a4e
Source dataset
uspto-grants-2004_04
Patent number
US06716987B1

Reaction notes

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