1-Bromo-3-chloropropane → HCID 22731956, compound

HRID 2084858Notes

Reaction equation

HRID 2084858 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH:4]([NH:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]#[C:21][CH3:22])=[CH:14]C=1)(=[O:11])=[O:10])[CH:5]([CH3:7])[CH3:6].Br[CH2:25][CH2:26][CH2:27][Cl:28]>>[CH2:19]([O:18][CH:15]([CH3:14])[CH2:16][CH2:17][CH2:12][S:9]([N:8]([CH2:25][CH2:26][CH2:27][Cl:28])[CH:4]([CH:5]([CH3:6])[CH3:7])[C:3]([O:2][CH3:1])=[O:23])(=[O:10])=[O:11])[C:20]#[C:21][CH3:22]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 54394859HCID 54394859, compound

Product 1

HCID 22731956HCID 22731956, compoundYield 76.1%

Procedure

According to the procedure of Example 5, 1.00 g (2.95 mmol) 2-(4-but-2-ynyloxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester and 0.88 mL (8.849 mmol) of 1-bromo-3-chloropropane provided 0.92 g of methyl 2-[{[4-(2-butynyloxy)pentyl]sulfonyl}(3-chloropropyl)amino]-3-methylbutanoate as a white solid. Electrospray Mass Spec 416.2 (M+H)+.

Sources & evidence

ORD record
ord-4d011bfff61a4ee0bffe7a0239671021
Source dataset
uspto-grants-2004_04
Patent number
US06716833B2

Reaction notes

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