Trifluoroacetic acid → HCID 22644740, compound

HRID 2084874Notes

Reaction equation

HRID 2084874 reaction equation
[CH3:1][N:2]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH2:21][C:22]#[CH:23])=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][C:4]([O:6]C(C)(C)C)=[O:5].FC(F)(F)C(O)=O>ClCCl>[CH3:1][N:2]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH2:21][C:22]#[CH:23])=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH2:3][C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86587113HCID 86587113, compound

Product 1

HCID 22644740HCID 22644740, compoundYield 866.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.160 g (0.047 mmol) of 2-(methyl{[4-(prop-2-ynylamino)phenyl]sulfonyl}amino)acetic acid, tert-butyl ester in 1 mL of dichloromethane was added 1 mL of trifluoroacetic acid and the reaction was stirred at room temperature for 19 h. Concentration of the mixture in vacuo provides 0.115 g (86%) of 2-(methyl{[4-(prop-2-ynylamino)phenyl]sulfonyl}amino)acetic acid as a brown glass. Electrospray Mass Spec 281.1 (M−H)−.

Sources & evidence

ORD record
ord-d5b26b9111ad46ea89764904113b95dc
Source dataset
uspto-grants-2004_04
Patent number
US06716833B2

Reaction notes

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