Lithium iodide → HCID 21304718, compound

HRID 2084954Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:26]2[CH2:31][CH2:30][S:29][C:28]([CH3:33])([CH3:32])[C@@H:27]2[C:34]([O:36]C)=[O:35])(=[O:25])=[O:24])=[CH:19][CH:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[I-].[Li+]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:26]2[CH2:31][CH2:30][S:29][C:28]([CH3:33])([CH3:32])[C@@H:27]2[C:34]([OH:36])=[O:35])(=[O:25])=[O:24])=[CH:19][CH:18]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 66321Lithium iodide

HCID 21304722HCID 21304722, compound

Product 1

HCID 21304718HCID 21304718, compound

Procedure

The methyl ester of methyl(3S)-4-{[4-({7-[(tert-butoxycarbonyl)amino]-2-heptynyl}oxy)phenyl]sulfonyl}-2,2-dimethyl-3-thiomorpholine carboxylate was converted into the analogous carboxylic acid using lithium iodide according to the procedure of Example 250 to provide (3S)-4-{[4-({7-[(tert-butoxycarbonyl)amino]-2-heptynyl}oxy)phenyl]sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxylic acid as a white solid. Electrospray Mass Spec: 541.2 (M+H)+.

Sources & evidence

ORD record: ord-550a836a178049489b76c3e9b7055336
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716833B2

Reaction notes

Loading…