Methyl iodide → HCID 22644780, compound

HRID 2084973Notes

Reaction equation

[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])C.[CH2:8]([O:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([N:22]2[CH:28]([C:29]([NH:31][OH:32])=[O:30])CCNCC2)(=[O:21])=[O:20])=[CH:15][CH:14]=1)[C:9]#[C:10][CH3:11].IC>CO.ClCCl.O>[CH2:8]([O:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([N:22]2[CH:28]([C:29]([NH:31][OH:32])=[O:30])[CH2:7][CH2:6][N:3]([CH3:1])[CH2:4][CH2:5]2)(=[O:20])=[O:21])=[CH:15][CH:14]=1)[C:9]#[C:10][CH3:11]

Participants

Conditions

Temperature: 0 °C

Procedure

Triethylamine (0.08 mL) was added to a suspension of the product of Example 292, 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-N-hydroxy-1,4-diazepane-5-carboxamide (0.10 g), in methanol (6 mL) to give a solution which was cooled to 0° C. Iodomethane (0.025 mL) was then added. After 30 min the reaction mixture was allowed to warm to 25° C. After 20 min additional iodomethane (0.02 mL) was added followed by additional triethylamine (0.015 mL). After 18 hours the reaction mixture was diluted with dichloromethane and water. The aqueous phase was washed with dichloromethane (3×). The combined organic extracts were dried over anhydrous sodium sulfate and concentrated in vacuo. The material obtained was combined with material from a previous reaction run on the same scale and chromatographed on silica gel to give 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-N-hydroxy-1-methyl-1,4-diazepane-5-carboxamide (0.067 g). Electrospray Mass Spec 382.2 (M+H)+.

Workup

customto give a solution which
temperatureto warm to 25° C
washThe aqueous phase was washed with dichloromethane (3×)
dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
concentrationconcentrated in vacuo
customThe material obtained
customchromatographed on silica gel

Sources & evidence

ORD record: ord-c0c0d270c1164e84a741bca235907465
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716833B2

Reaction notes

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