反应详情

In a three necks 500 ml flask were introduced, in the following order, 65 g (451 mmol) of (cyclopentyloxy)acetic acid (obtained according to U.S. Pat. No. 4,735,932), 1.4 g of para-toluenesulfonic acid and 280 ml of MeOH. After 6 hours at reflux, the reaction mixture was cooled at room temperature diluted into 300 ml of water and extracted with 300 ml of ether. The organic phase thus obtained was washed twice with water, dried over MgSO4 and concentrated. It was thus obtained 56.9 g of product (yield=80%) having a GC purity of 99%.

1. customobtained
2. temperatureAfter 6 hours at reflux
3. extractionextracted with 300 ml of ether
4. customThe organic phase thus obtained
5. washwas washed twice with water
6. dry with materialdried over MgSO4
7. concentrationconcentrated