Trifluoroacetic acid → HCID 10144716, compound

HRID 2085117Notes

Reaction equation

HRID 2085117 reaction equation
[CH3:1][O:2][C:3](=[O:33])[C@@H:4]([NH:17][C:18]([C@@H:20]1[CH2:32][C:31]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[NH:24][C:23]=2[CH2:22][NH:21]1)=[O:19])[CH2:5][CH2:6][CH2:7][CH2:8][NH:9]C(OC(C)(C)C)=O.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.C(O)(C(F)(F)F)=O>>[CH3:1][O:2][C:3](=[O:33])[CH:4]([NH:17][C:18]([CH:20]1[CH2:32][C:31]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[NH:24][C:23]=2[CH2:22][N:21]1[S:40]([C:37]1[CH:36]=[CH:35][C:34]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[CH:39][CH:38]=1)(=[O:42])=[O:41])=[O:19])[CH2:5][CH2:6][CH2:7][CH2:8][NH2:9]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 69887620HCID 69887620, compound

Product 1

HCID 10144716HCID 10144716, compound

Procedure

6-Amino-2-{[2-(biphenyl-4-sulfonyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carbonyl]-amino}-hexanoic acid methyl ester was prepared according to the above procedure from 6-tert-Butoxycarbonylamino2-(S)-[(2,3,4,9-tetrahydro-1H-β-carboline-3-(S)-carbonyl)-amino]-hexanoic acid methyl ester (37 mg, 0.08 mmol) and biphenyl-4-sulphonyl chloride (24 mg, 0.1 mmol) to deliver 6 mg of the TFA salt. MS (APCI) M+575.5

Sources & evidence

ORD record
ord-d990f2c27b874b4198162c2c81f8a0c2
Source dataset
uspto-grants-2004_04
Patent number
US06720330B2

Reaction notes

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