Acetylglycine → HCID 361416, compound

HRID 2085203Notes

Reaction equation

HRID 2085203 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6](C=O)=[CH:7][CH:8]=1.[C:11]([NH:14][CH2:15][C:16]([OH:18])=[O:17])(=O)[CH3:12].[C:19]([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:19]=[C:15]1[C:16](=[O:17])[O:18][C:11]([CH3:12])=[N:14]1

Participants

5

Reactant 3

HCID 10972AcetylglycineHCID 312444-MethoxybenzaldehydeHCID 517045Sodium Acetate

Product 1

HCID 361416HCID 361416, compoundYield 52.8%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
100 °C

Procedure

Anisaldehyde (11.3 g), N-acetylglycine (9.8 g) and sodium acetate (8.2 g) were dissolved in acetic anhydride (200 ml) and the mixture was heated at 100° C. for 10 hr. After cooling, the precipitated yellow crystals were collected by filtration to give the title compound (9.52 g), melting point 151-153° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated yellow crystals were collected by filtration

Sources & evidence

ORD record
ord-5cbfa1891c4d4b00b3ad2748f650f142
Source dataset
uspto-grants-2004_04
Patent number
US06720320B2

Reaction notes

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