Thionyl Chloride → HCID 22282584, compound

HRID 2085345Notes

Reaction equation

HRID 2085345 reaction equation
S(Cl)([Cl:3])=O.[O:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]2[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][CH:16]=2)=[CH:7][CH2:6]1>ClCCl>[O:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]2[CH:23]=[CH:22][C:18]([C:19]([Cl:3])=[O:20])=[CH:17][CH:16]=2)=[CH:7][CH2:6]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22282647HCID 22282647, compound

Product 1

HCID 22282584HCID 22282584, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (2 mL) was added to a suspension of 4-(2H-chromen-4-yl)benzoic acid from reaction 34c (0.415 g, 1.6 mmol) in dichloromethane (10 mL) at room temperature. The reaction was stirred for 4 h, concentrated in vacuo to give 4-(2H-chromen-4-yl)benzoyl chloride (0.445 g, 99%) as a yellow solid.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-898ad14979704cb48529cba8deeebee5
Source dataset
uspto-grants-2004_04
Patent number
US06720329B2

Reaction notes

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