Piperidine → HCID 22725230, compound

HRID 2085412Notes

Reaction equation

HRID 2085412 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1[F:10])[CH:5]=O.[CH3:12][C:13](=[O:18])[CH2:14][C:15](=[O:17])[CH3:16].N1CCCCC1>C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1[F:10])[CH:5]=[C:14]([C:13](=[O:18])[CH3:12])[C:15](=[O:17])[CH3:16]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 31261AcetylacetoneHCID 27769543,4,5-Trifluorobenzaldehyde

Product 1

HCID 22725230HCID 22725230, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A stirring mixture of 3,4,5-trifluorobenzaldehyde (4.20 g, 26.2 mmol), 2,4-pentanedione (2.62 g, 26.2 mmol), piperidine (0.430 g, 5.00 mmol) in benzene (150 mL) was heated at reflux temperature in a Dean-Stark apparatus for 8 h. The benzene was evaporated and the yellow oily residue was used in the next step without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature in a Dean-Stark apparatus for 8 h
  3. customThe benzene was evaporated
  4. customthe yellow oily residue was used in the next step without further purification

Sources & evidence

ORD record
ord-53ac31ea175b4370b76224ba83a795ac
Source dataset
uspto-grants-2004_04
Patent number
US06720324B2

Reaction notes

Loading…