Piperidine → HCID 22725230, compound

HRID 2085429Notes

Reaction equation

HRID 2085429 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1[F:10])[CH:5]=O.[CH3:12][C:13](=[O:18])[CH2:14][C:15](=[O:17])[CH3:16].N1CCCCC1>C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:14]([C:13](=[O:18])[CH3:12])[C:15](=[O:17])[CH3:16])[CH:7]=[C:8]([F:11])[C:9]=1[F:10]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 31261AcetylacetoneHCID 27769543,4,5-Trifluorobenzaldehyde

Product 1

HCID 22725230HCID 22725230, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A stirring mixture of 3,4,5-trifluorobenzaldehyde (4.2 g, 26.2 mmol), 2,4-pentanedione (2.62 g, 26.2 mmol), piperidine (0.430 g, 5 mmol) in benzene (150 mL) was heated at reflux temperature (equipped with a Dean-Stark trap) for 8 h. The benzene was evaporated, the yellow oily residue, 2-{(3,4,5-trifluorophenyl)-methylene}-2,4-pentanedione, was used in the next step without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature (
  3. customequipped with a Dean-Stark trap) for 8 h
  4. customThe benzene was evaporated
  5. customthe yellow oily residue, 2-{(3,4,5-trifluorophenyl)-methylene}-2,4-pentanedione, was used in the next step without further purification

Sources & evidence

ORD record
ord-0cc7ddbe7efe4d098d8c597a78cc08d5
Source dataset
uspto-grants-2004_04
Patent number
US06720324B2

Reaction notes

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