反应详情

A stirred mixture of one mole equivalent of methyl (4R)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (10.0 g, 32.0 mmol) and lithium hydroxide (2 equivalents, 1.53 g, 64.0 mol) in H2O-THF (2:1, 300 mL) was heated at reflux temperature for 1 h. The reaction mixture was concentrated, dissolved in water, washed with ethyl acetate and acidified (1 N HCl) to pH 3-4 (pH paper). The precipitated product was collected, washed with water and dried under reduced pressure to give the desired product in 90% yield.

1. temperaturewas heated
2. temperatureat reflux temperature for 1 h
3. concentrationThe reaction mixture was concentrated
4. dissolutiondissolved in water
5. washwashed with ethyl acetate
6. customThe precipitated product was collected
7. washwashed with water
8. customdried under reduced pressure