HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Amino-2-methylpropyl)dimethylamine → Ammonium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Amino-2-methylpropyl)dimethylamine | HCID 226843 | — |
| Reactant | 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic Acid | HCID 11257352 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Product | Ammonium Hydroxide | HCID 14923 | 58% |
| Product | 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-N-(2-dimethylamino-1,1-dimethyl-ethyl)-benzamide Dihydrochloride | HCID 22731073 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Step 3 of Method A, from 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid (3) and 2,N1,N1-trimethyl-propane-1,2-diamine (Tsuji, et al Chem. Pharm. Bull. Vol. 12, pp. 946-950 (1964)). Radial chromatography with 0.5% (58% NH4OH)/5%MeOH/CHCl3 gave a yellow oil, which was placed in CHCl3, treated with 4M HCl in dioxane (2.2 equiv), and azeotroped from CHCl3 in succession to provide 100 mg of yellow powder in 23% yield, mp 275-290° C. (decomp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720346B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-d6369c890bb946b49fff00c8c4f1a7e2 |
| Source note | uspto-grants-2004_04 |