HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(aminomethyl)-N,N-dimethylcyclopentan-1-amine → 4-{[4-Amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino}-N-{[1-(dimethylamino)cyclopentyl]methyl}benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(aminomethyl)-N,N-dimethylcyclopentan-1-amine | HCID 10844493 | — |
| Reactant | 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic Acid | HCID 11257352 | — |
| Product | 4-{[4-Amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino}-N-{[1-(dimethylamino)cyclopentyl]methyl}benzamide | HCID 22731063 | 62% |
Reaction Steps
The title compound was prepared in a manner similar to Step 3 in Method A; from coupling 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid (3) and 1-(aminomethyl)-N,N-dimethylcyclopentanamine (Yang et al., Eur. J. Med. Chem. 31, 231-239 (1996)) to afford a yellow amorphous powder in 62% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720346B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-04206c419d024c7e8edf1cc91ae9376e |
| Source note | uspto-grants-2004_04 |