Hydrochloric Acid → HCID 10139172, compound

HRID 2085634Notes

Reaction equation

HRID 2085634 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])=[CH:4][C:3]=1[C:20](=[O:33])[NH:21][CH2:22][C:23]12[CH2:32][CH:27]3[CH2:28][CH:29]([CH2:31][CH:25]([CH2:26]3)[CH2:24]1)[CH2:30]2.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:4][C:3]=1[C:20](=[O:33])[NH:21][CH2:22][C:23]12[CH2:30][CH:29]3[CH2:31][CH:25]([CH2:26][CH:27]([CH2:28]3)[CH2:32]1)[CH2:24]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131724405HCID 131724405, compound

Product 1

HCID 10139172HCID 10139172, compoundYield 12.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To [2-[4-chloro-3-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)carbamoyl-phenylamino]-ethylamino]-acetic acid, 1,1-dimethylethyl ester (0.10 g, Example 2a) was added a solution of HCl in dioxane (5 ml of a 4M solution) and reaction mixture stirred at room temperature for 48 h before concentration under reduced pressure. The residue was recrystallised twice from propan-2-ol/ethyl acetate/ether mixture to afford the title compound as a white solid (0.006 g).

Workup

  1. customreaction mixture
  2. customThe residue was recrystallised twice from propan-2-ol/ethyl acetate/ether mixture

Sources & evidence

ORD record
ord-40d9a2af777144979fb2448b2637699d
Source dataset
uspto-grants-2004_04
Patent number
US06720452B2

Reaction notes

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