Pyridine → HCID 22730448, compound

HRID 2085739Notes

Reaction equation

HRID 2085739 reaction equation
Cl[C:2](=[O:25])[CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:12]([C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.N1C=CC=CC=1>O1CCOCC1>[CH3:26][N:27]1[CH2:32][CH2:31][N:30]([C:2](=[O:25])[CH2:3][CH2:4][C:5]2[CH:14]=[CH:13][C:12]([C:15]3[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=3)=[C:11]3[C:6]=2[CH:7]=[CH:8][CH:9]=[N:10]3)[CH2:29][CH2:28]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 531671-MethylpiperazineHCID 22730840HCID 22730840, compound

Product 1

HCID 22730448HCID 22730448, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of Example 201I (300 mg, 0.85 mmol), 1-methylpiperazine (111 mg, 1.11 mmol), and pyridine (74 mg, 0.94 mmol) in dioxane (4 mL) at room temperature was stirred for 75 minutes and purified by flash column chromatography on silica gel with 90:10:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product.

Workup

  1. custompurified by flash column chromatography on silica gel with 90:10:0.5 dichloromethane/methanol/concentrated ammonium hydroxide

Sources & evidence

ORD record
ord-3238390ad6d946eb8bf7996d45e2dce0
Source dataset
uspto-grants-2004_04
Patent number
US06720338B2

Reaction notes

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