HCID 68454581, compound → HCID 68452223, compound

HRID 2085778Notes

Reaction equation

HRID 2085778 reaction equation
[CH3:1][C@:2]12[C:8]([CH3:10])([CH3:9])[C@H:5]([CH2:6][CH2:7]1)[CH:4]=[C:3]2[C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=1>C(OCC)(=O)C.C(O)C.[Pd]>[CH3:1][C@:2]12[C:8]([CH3:9])([CH3:10])[C@H:5]([CH2:6][CH2:7]1)[CH2:4][CH:3]2[C:11]1[CH:12]=[CH:13][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:19][CH:20]=1

Participants

5

Reactant 1

HCID 68454581HCID 68454581, compound

Product 1

HCID 68452223HCID 68452223, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of Example 372B (100 mg) and 10% Pd/C (20 mg) in ethyl acetate (5 mL) and ethanol (5 mL) at room temperature was stirred under H2 for 18 hours, filtered, and concentrated to provide the desired product. MS (DCI(+)) m/e 245 (M+H)+.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-067b95e66085446da5dea94145f06a24
Source dataset
uspto-grants-2004_04
Patent number
US06720338B2

Reaction notes

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