反应详情

温度

0 °C

A solution of Example 1D (1.0 g) in methanol (10 mL) and concentrated aqueous ammonia (3 mL) was heated in a sealed pressure tube to 60° C. for 16 hours, cooled to 0° C., diluted with ethyl acetate (100 mL), washed with water (30 mL) and brine (10 mL), dried (MgSO4), filtered, and concentrated to provide the desired product.

1. washwashed with water (30 mL) and brine (10 mL)
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated