Water → 6-(4-Chlorobenzylamino)-3-(2,6-difluorophenyl)-[1,2,4]triazine

HRID 2085923Notes

Reaction equation

HRID 2085923 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:15])=[N:4][CH:3]=1.[Cl:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19][CH:18]=1.C(N(CC)CC)C.O>C(Cl)Cl>[Cl:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH:22][C:2]2[N:7]=[N:6][C:5]([C:8]3[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=3[F:15])=[N:4][CH:3]=2)=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 660364-ChlorobenzylamineHCID 227270216-Chloro-3-(2,6-difluorophenyl)-[1,2,4]triazine

Product 1

HCID 227270286-(4-Chlorobenzylamino)-3-(2,6-difluorophenyl)-[1,2,4]triazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.9 g of 6-chloro-3-(2,6-difluorophenyl)-[1,2,4]triazine is placed in 10 ml of methylene chloride, and 0.57 g of 4-chlorobenzylamine and 0.81 g of triethylamine are added. After being stirred at room temperature for 2 h, the reaction mixture is poured into water and extracted with methylene chloride; the organic phase is concentrated and the residue is purified by means of column chromatography over silica gel. In this way the title compound having a melting point of 200-205° C. is obtained.

Workup

  1. extractionextracted with methylene chloride
  2. concentrationthe organic phase is concentrated
  3. customthe residue is purified by means of column chromatography over silica gel
  4. customis obtained

Sources & evidence

ORD record
ord-df3ac94ab81f41bb91840703d24114a8
Source dataset
uspto-grants-2004_04
Patent number
US06723720B2

Reaction notes

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