反应详情

140 mg of 1-(4-chlorophenyl)-2-[3-(2,6-difluorophenyl)-[1,2,4]triazin-6-yl]-ethanol and 10 mg of p-toluenesulfonic acid in 10 ml of toluene are boiled under reflux using a water separator for 2 h; the reaction mixture is then poured into water, and the toluene phase is separated off, dried with sodium sulfate and concentrated by evaporation. After recrystallisation of the residue from cyclohexane, the title compound having a melting point of 135-140° C. is obtained.

1. temperatureunder reflux
2. customthe toluene phase is separated off
3. dry with materialdried with sodium sulfate
4. concentrationconcentrated by evaporation
5. customAfter recrystallisation of the residue from cyclohexane
6. customis obtained