HCID 22727488, compound → HCID 22727497, compound

HRID 2085932Notes

Reaction equation

HRID 2085932 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15]C(OC(C)(C)C)=O>FC(F)(F)C(O)=O>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][NH2:15]

Participants

3

Reactant 1

HCID 22727488HCID 22727488, compound

Product 1

HCID 22727497HCID 22727497, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
0 °C

Procedure

198 mg (0.65 mmol) of 4-(benzimidazol-2-ylamino)-1-(tert-butyloxycarbonylamino)butane (Example 23c) were dissolved in 20 ml of 95% strength trifluoroacetic acid at 0° C. and stirred at 0° C. for 2 h, then concentrated at RT during the course of 30 min. The residue was coevaporated three times with toluene, then stirred with ether and washed with pentane and dried in vacuo. Yield: 100%. MS (ES+): m/e=205.2 ( (M+H)+, 100%).

Workup

  1. concentrationconcentrated at RT during the course of 30 min
  2. stirringstirred with ether
  3. washwashed with pentane
  4. customdried in vacuo

Sources & evidence

ORD record
ord-3aee8acaf0b944b4be6899728fd2869c
Source dataset
uspto-grants-2004_04
Patent number
US06723727B1

Reaction notes

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