Dimethylamine → 6-(N,N-Dimethylamino)-3H-pyrido[3,4-d]pyrimidin-4-one

HRID 2085940Notes

Reaction equation

HRID 2085940 reaction equation
Cl[C:2]1[N:12]=[CH:11][C:5]2[N:6]=[CH:7][NH:8][C:9](=[O:10])[C:4]=2[CH:3]=1.[CH3:13][NH:14][CH3:15]>C(O)C>[CH3:13][N:14]([C:2]1[N:12]=[CH:11][C:5]2[N:6]=[CH:7][NH:8][C:9](=[O:10])[C:4]=2[CH:3]=1)[CH3:15]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 1354805256-chloro-3H,4H-pyrido[3,4-d]pyrimidin-4-one

Product 1

HCID 1358174466-(N,N-Dimethylamino)-3H-pyrido[3,4-d]pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
130 °C

Procedure

Alternatively, 6-chloro-pyrido[3,4-d]pyrimidin-4-one (26.14 g) was treated with 2N dimethylamine in ethanol (200 ml) and heated at 130° C. in a Parr bomb for 3 days. The cooled mixture was filtered and triturated from isopropanol to give the title compound (16.61 g) as a yellow solid; m/z (M+1+) 191.

Workup

  1. filtrationThe cooled mixture was filtered
  2. customtriturated from isopropanol

Sources & evidence

ORD record
ord-191c335caac94d5bb70101d12843b288
Source dataset
uspto-grants-2004_04
Patent number
US06723726B1

Reaction notes

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